THE EFFECT OF 2,4-DINITROPHENOL AND PHAGE T2 ON ESCHERICHIA COLI B

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Abstract
Simultaneous infection with phage T2r+ and inhibition by 2,4-dinitrophenol is followed by immediate lysis of 3-hr. cultures of E. coli B in Difco nutrient broth or in a synthetic medium containing ammonia, salts, and glucose or lactose, or no carbohydrate. The infecting phage is lost and no new phage is produced. Dinitrophenol inhibits lysis of E. coli B infected with phage T2r or with phage Tl. In synthetic medium without carbohydrate, infection with phage T2r+ is followed by immediate lysis even in the absence of dinitrophenol. In synthetic medium without carbohydrate, exposure of an uninfected culture of E. coli B to dinitrophenol is followed by partial lysis.