Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance
- 1 July 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 38 (7) , 1146
- https://doi.org/10.1212/wnl.38.7.1146
Abstract
Addition of carbamazepine to phenytoin monotherapy resulted in the following significant (p < 0.05) changes: (1) increased mean phenytoin serum concentration; (2) decreased phenytoin clearance, due to decreased production of phenytoin dihydrodiol and p-hydroxyphenyl-phenylhydantoin; (3) increased phenytoin elimination half-life; and (4) increased drug-related toxicity. Close monitoring is required after addition of carbamazepine to phenytoin.This publication has 0 references indexed in Scilit: