PROTECTION OF THE TRYPTOPHAN INDOLE RING IN PEPTIDE SYNTHESIS. USE OF A NEW DERIVATIVE, Nin-2,2,2-TRICHLOROETHOXYCARBONYLTRYPTOPHAN
- 5 May 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 12 (5) , 739-742
- https://doi.org/10.1246/cl.1983.739
Abstract
The 2,2,2-trichloroethoxycarbonyl (Troc) group attached at the Nin function of tryptophan by acylation with Troc-Cl in the presence of a catalytic amount of tetra-n-butylammonium hydrogensulfate can be quantitatively removed either by cadmium dust in acetic acid or under basic conditions, e.g., hydrazine hydrate and NaOH, but is resistant to strong acidic conditions.Keywords
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