Red Blood Cell Lithium Index in Patients with Affective Disorders in the Course of Lithium Prophylaxis

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Abstract
Red blood cell (RBC) lithium index (RBC lithium:serum lithium ratio) was estimated in 37 patients with affective disorders in the course of lithium prophylaxis during 4 months. The study revealed no difference in RBC lithium index between patients with manic-depressive psychosis and unipolar depression, as well as between men and women. RBC lithium index was to some extent correlated to the magnitude of serum lithium concentration. The variability of RBC lithium index with time was different in different patients ranging from ±2 to ± 50 %. The possible importance of RBC lithium index in affective disorders is critically discussed.

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