ACUTE ABDOMINAL MANIFESTATIONS IN SICKLE CELL DISEASE

1 November 1949

journal article
research article
Published by American Medical Association (AMA) in Archives of Surgery

Vol. 59 (5) , 993-1000
https://doi.org/10.1001/archsurg.1949.01240041003001

Abstract

ONLY a small proportion of Negroes with the sickle cell trait have the active form of the disease.¹ In 1929 Levy² found that of 213 Negroes admitted in succession to the New Rochelle Hospital, 12, or 5.8 per cent, had "sickling." Murphy and Shapiro³ recorded its incidence in the North American Negro as from 7 to 13 per cent, with anywhere from 1 in 7 to 1 in 40 of those affected showing clinical disease and with a total of almost 135,000 diseased in the United States. Wintrobe⁴ expressed the belief that 1 in 40 Negroes in North America and up to 9 per cent in Central and South America are so affected. Huck⁵ first pointed out that the trait was transmitted by the male and the female as a mendelian dominant characteristic. It occurs in males in a ratio of 3 to 1⁶; usually children and adolescents are affected, though

Keywords

ANEMIA

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