Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors
- 1 October 2004
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 12 (19) , 5147-5160
- https://doi.org/10.1016/j.bmc.2004.07.027
Abstract
No abstract availableKeywords
This publication has 30 references indexed in Scilit:
- Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam NitrogenJournal of Medicinal Chemistry, 2003
- Design, Synthesis, and Biological Evaluation of Cytotoxic 11-Alkenylindenoisoquinoline Topoisomerase I Inhibitors and Indenoisoquinoline−Camptothecin HybridsJournal of Medicinal Chemistry, 2003
- The mechanism of topoisomerase I poisoning by a camptothecin analogProceedings of the National Academy of Sciences, 2002
- Cellular roles of DNA topoisomerases: a molecular perspectiveNature Reviews Molecular Cell Biology, 2002
- Synthesis of New Dihydroindeno[1,2-c]isoquinoline and Indenoisoquinolinium Chloride Topoisomerase I Inhibitors Having High in Vivo Anticancer Activity in the Hollow Fiber Animal ModelJournal of Medicinal Chemistry, 2001
- Modulation of camptothecin analogs in the treatment of cancer: a reviewAnti-Cancer Drugs, 2001
- Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I InhibitorsJournal of Medicinal Chemistry, 2000
- Synthesis of Cytotoxic Indenoisoquinoline Topoisomerase I PoisonsJournal of Medicinal Chemistry, 1999
- Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I PoisonMolecular Pharmacology, 1998
- A Model for the Mechanism of Human Topoisomerase IScience, 1998