Synthesis of Murisolin, (15R, 16R, 19R, 20S)‐Murisolin A, and (15R, 16R, 19S, 20S)‐16,19‐cis‐Murisolin and Their Inhibitory Action with Bovine Heart Mitochondrial Complex I
- 7 December 2006
- journal article
- research article
- Published by Wiley in Chemistry – An Asian Journal
- Vol. 1 (6) , 894-904
- https://doi.org/10.1002/asia.200600261
Abstract
The asymmetric total synthesis of murisolin, (15R, 16R, 19R, 20S)‐murisolin A, and (15R, 16R, 19S, 20S)‐16,19‐cis‐murisolin was performed by using an epoxy alcohol as a versatile chiral building block for synthesizing the stereoisomers of mono‐THF annonaceous acetogenins. The inhibitory activity of these murisolin compounds was examined with bovine heart mitochondrial complex I, and they showed almost the same activity.Keywords
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