PATHOLOGIC LESIONS PRODUCED BY SULFATHIAZOLE

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Abstract
We are presenting 4 fatal cases of sulfathiazole treatment in which autopsy revealed histopathologic lesions not characteristic of any previously described disease process. Rake, Van Dyke and Corwin1described identical pathologic lesions in their experimental work on mice inoculated with sulfathiazole. They stated that 77 per cent of the mice given a 2 per cent sulfathiazole diet died during a four week period and that the lesions were chiefly in the spleen and the genitourinary tract. They reported tuberculous-like lesions in sulfathiazole treated monkeys; they attributed these lesions to tuberculosis. However, in the kidneys from these monkeys they demonstrated crystals surrounded by leukocytic zones. The microscopic lesions are so similar to the focal necrosis seen in infections that no doubt many cases since the introduction of the drug have been overlooked. To report, we selected 4 cases in which we feel that the lesions were clearcut and could not

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