Comparison of the Efficacy of “Trisdine” and Kanamycin-Colistin Bladder Instillations in Reducing Bacteriuria during Intermittent Catheterisation of Patients with Acute Spinal Cord Trauma

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Abstract
Summary— An open, prospective, randomised, comparative study of “Trisdine” and kanamycincolistin bladder instillations in reducing significant bacteriuria during intermittent urethral catheterisation was conducted. Trisdine is an aqueous solution of chlorhexidine gluconate 0.01% with added ethylenediaminetetra‐acetic acid disodium salt and TRIS buffer at final concentrations of 1.34 mMoles and 0.01 Molar respectively. All patients (15 males and 3 females) admitted with acute spinal cord trauma and bladder involvement requiring intermittent catheterisation for more than 5 days during a 12‐month period were studied. There was no significant difference in the mean incidence of significant bacteriuria during intermittent catheterisation in the 7 males who had kanamycin‐colistin bladder instillations compared with the 8 males who had Trisdine instillations. A comparison could not be made in the females because there were only 3 patients. Because Trisdine is more stable at ambient temperatures, is less likely to select antibiotic‐resistant bacteria and is less expensive, it is concluded that Trisdine is preferable to kanamycin‐colistin solution for bladder instillations during intermittent catheterisation.