Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation
- 21 July 2006
- journal article
- review article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 34 (4) , 523-525
- https://doi.org/10.1042/bst0340523
Abstract
Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases.Keywords
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