CYCLOPHOSPHAMIDE, VINCRISTINE, AND THE BLOOD TESTIS BARRIER

  • 1 January 1981
    • journal article
    • research article
    • Vol. 18  (6) , 443-444
Abstract
The blood testis barrier has been implicated in the pathogenesis of testicular relapse of childhood acute leukemia by forming a sanctuary site for leukemic cells. The transport of [the antineoplastic drugs] 14C-cyclophosphamide and 3H-vincristine across the blood testis barrier was tested. Both cyclophosphamide and vincristine crossed the blood testis barrier. Other factors such as the transport of Ig and leukocytes across the blood testis barrier may interact in the pathogenesis of leukemic testicular relapse.

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