Elevated Threshold for Thyrotropin Suppression in Congenital Hypothyroidism
- 1 January 1980
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Pediatrics & Adolescent Medicine
- Vol. 134 (1) , 19-20
- https://doi.org/10.1001/archpedi.1980.02130130011004
Abstract
• Five infants with congenital hypothyroidism were found to have persistently elevated levels of serum thyrotropin (TSH) for six to 24 months after administration of adequate doses of thyroxine. In these infants, the hypothalamic-pituitary threshold for TSH suppression by thyroxine seems to be unusually high. These observations suggest that serum TSH levels should not be the sole criterion for evaluating adequacy of thyroid hormone replacement during the initial months of therapy for congenital hypothyroidism. (Am J Dis Child 134:19-20, 1980)This publication has 4 references indexed in Scilit:
- Age-Related Change in Pituitary Threshold for TSH Release During Thyroxine Replacement Therapy for CretinismJournal of Clinical Endocrinology & Metabolism, 1977
- Evaluation of sodium l-thyroxine (T4) requirement in replacement therapy of hypothyroidismThe Journal of Pediatrics, 1977
- Reassessment of the daily dose of oral thyroxine for replacement therapy in hypothyroid childrenThe Journal of Pediatrics, 1977
- Suppression of Thyrotropin (H-TSH) in Serums of Patients with Myxedema of Varying Etiology Treated with Thyroid HormonesNew England Journal of Medicine, 1971