Age‐dependent β‐adrenergic response of neuronal discharge in the raphe dorsalis: Evidence of a transient regulation

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Abstract
Extracellular recordings from raphe dorsalis neurons in rats during development were performed, and the response to iontophoretically applied β-antagonists was analysed. In pups younger than 2 weeks, raphe dorsalis firing was totally or partially inhibited by application of β-antagonists, while after 2 weeks of age the neurons were insensitive to the same application. The β-receptors appeared to be involved in the control of raphe firing during a transient period of ontogenesis and thus the disappearance of β-regulation at older ages may reflect the regression of this population of neurotransmitter receptors.