CHOLESTEROL BIOSYNTHESIS IN AN ADRENAL TUMOR1
- 1 November 1953
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 53 (5) , 506-511
- https://doi.org/10.1210/endo-53-5-506
Abstract
A human adrenal tumor was shown to utilize Na acetate-1- C14 as substrate for the synthesis of cholesterol in isolated organ perfusion. The presence of unidentified materials, co-precipitated with cholesterol by digitonin and removed from cholesterol only with difficulty, was demonstrated in the tumor sterol fraction. Careful assay of each chromatographic fraction for radioactivity or purification via the dibromide was found to be necessary for a radiochemically pure sample.Keywords
This publication has 3 references indexed in Scilit:
- Biosynthesis of CholesterolAmerican Journal of Physiology-Legacy Content, 1952
- Biosynthesis of 17-α-hydrozycorticosterone from acetateArchives of Biochemistry and Biophysics, 1951
- THE IN VITRO SYNTHESIS OF CHOLESTEROL FROM ACETATE BY SURVIVING ADRENAL CORTICAL TISSUEJournal of Biological Chemistry, 1948