Microbiological Studies of Some New Penicillins in Vitro and in Vivo

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Abstract
Six penicillin varieties, benzyl-phenoxymethyl -, phenoxyethyl -, p-aminobenzy-, p-acetamidobenzyl-and p-aminophenoxymethylpenicillin, were compared as to activity against different organisms. Considerable differences observed are correlated to the chemical differences between the compounds. The maximum levels and durations of penicillin concentration in serum were studied in convalescent patients and the differences correlated to the chemical constitution of the drugs. Although the antibacterial activity of the patient''s serum is the most relevant basis for predicting therapeutic results in individual cases, drug concentration and activity as underlying factors are important in systematic study of antibiotics.

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