Flow Cytometric DNA Analysis of Bone Tumors

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Abstract
It is the foremost objective of every tumor Classification to help to determine prognosis. The definition of morphological categories is the generally accepted principle of all current classifications. In bone tumor pathology, the spectrum of morphological criteria has been enlarged by roentgenological features; nevertheless, their Classification is often more difficult than that of carcinomatous neoplasms (Schajowicz etal. 1972; Schajowicz 1981). This is due not only to the great morphological heterogeneity of bone tumors but also to the close topographical relationship between tumor tissue and the often very similar mesenchymal changes of inflammatory, reactive, or strongly proliferative nature. A major feature is the presence of multinucleated, histiocytic giant cells in bone tumors. Though varying in intensity, the occurrence of giant cells is a typical trait. Differential diagnostic problems are encountered, especially in the morphological distinction of purely reactive alterations from well-differentiated but potentially malignant neoplasms (e.g., parosteal osteosarcoma), and of benign from malignant tumorous lesions (e.g., benign and malignant giant cell tumors).