Detection of Achlorhydria by Indirect Gastric Analysis

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Abstract
IN an effort to avoid the unpleasantness of obtaining gastric contents for analysis, Segal et al.1 devised a practical "tubeless" method employing a cation-exchange resin (Amberlite XE-96) combined with a special indicator cation (quinine hydrochloride). In the stomach, beginning at pH 3, but at an optimum pH of 1.5, the quinine is displaced by hydrogen ions, absorbed and excreted in the urine. The method has not enjoyed great popularity, since the detection of the resulting fluorescent compound in the urine requires special apparatus. Other drugs that give the same fluorescence have led to false-positive tests.The combination of Amberlite XE-96 . . .