The HLA Antigens in Women with Recurrent Abnormal Pregnancies of Unknown Etiology

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Abstract
Women with recurrent abnormal pregnancies of unknown etiology—as compared with those with recurrent abnormal pregnancies of known etiology and with normal controls—had a significantly increased frequency of antigen HLA—A9 (corr. P < 0.01). Analysis of the frequencies in matings performed at different levels of HLA incompatibility between parents in 35 couples with recurrent abnormal pregnancies of unknown etiology revealed a high degree of wife husband compatibility of the antigens of the HLA—A locus, but not of the antigens of the HLA—B locus. These results indicate that the HLA chromosomal region may influence the reproductive efficiency and the fate of the fetus.