Chemical and Immunological Studies of the Pneumococcus

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Abstract
Summary: From type I pneumococcus cells a specific substance, apparently carbohydrate in nature, was isolated. Its properties and antigenic activity are described as follows: Precipitation occurred with type I antipneumococcus serum in a dilution of 1:6,000,000; also, in a dilution of 1:600,000 with type I antipneumococcus serum from which the antibodies against the specific carbohydrate of Heidelberger and Avery had been adsorbed.Complement was fixed in the presence of type I antipneumococcus rabbit serum.Protein tests were negative and carbohydrate, positive.Mice immunized with it were protected against type I pneumococcus infection.It caused fatal anaphylactic shock in guinea pigs passively sensitized with type I antipneumococcus rabbit serum; also, in guinea pigs passively sensitized with type I antipneumococcus rabbit serum from which the antibodies against the specific carbohydrate of Heidelberger and Avery had been absorbed.

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