Snake Venoms. The Amino-Acid Sequence of Trypsin Inhibitor E of Dendroaspis polylepis polylepis (Black Mamba) Venom

Abstract
Trypsin inhibitor E from black mamba venom comprises 59 amino acid residues in a single polypeptide chain, cross-linked by 3 intrachain disulfide bridges. The complete primary structure of inhibitor E was elucidated. The sequence is homologous with trypsin inhibitors from different sources. Unique among this homologous series of proteinase inhibitors, inhibitor E has an affinity for transition metal ions, exemplified here by Cu2+ and Co2+.