Tumor Suppression by Cell Walls of Mycobacterium bovis Attached to Oil Droplets

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Abstract
The growth of syngeneic guinea-pig tumor transplants in skin was suppressed if the tumor cells were inoculated together with bacillus Calmette-Guérin (BCG) cell walls attached to oil droplets. Tumor growth was not inhibited if the tumor cells were given together with 1) BCG cell walls, 2) oil droplets, and 3) oil droplets and BCG cell walls prepared so as to prevent attachment of the walls to the oil droplets. Animals in which tumor growth was suppressed acquired systemic tumor immunity.