RESULTS OF RADIOIODINE THERAPY OF AUTONOMOUS THYROID ADENOMAS WITH REFERENCE TO REGIONAL IODINE KINETICS AND PARANODULAR UPTAKE

  • 1 January 1983
    • journal article
    • research article
    • Vol. 22  (4) , 187-191
Abstract
In 110 patients with autonomous adenoma of the thyroid, the success rate of therapy with radioiodine using different local dosages (300 and 400 Gy [Gray]) was monitored. The relative paranodular uptake before and after radiotherapy was compared regarding dependence on the duration of therapy. In a short period of therapy (5-8 days) the paranodular uptake decreased as compared to a long duration (9-20 days), where it increased. This explains the higher rate of hypothyroidism found in the group of patients with a longer period of therapy. The success rate was 93.6% after applying a dosage of 300 Gy and 95% after 400 Gy. A slightly smaller incidence of hypothyroidism (3.2%) was found after 300 Gy than after 400 Gy (8.8%). Nevertheless, the higher dosage should be chosen to reduce the failure rate. Because of the increased rate of hypothyroidism with increasing paranodular uptake, it is recommended that in cases with uptake ratios between 10 and 20% (so-called transitional type) exogenic suppression of the paranodular tissue be induced by means of thyroid hormone.

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