Inhibition of Tumor-Promoter-Enhanced 3H-Choline Incorporation into Cellular Phospholipids by Phloroglucinol Derivatives from Mallotus japonicus
- 1 September 1991
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 54 (5) , 1409-1412
- https://doi.org/10.1021/np50077a029
Abstract
The MeOH and CHCl3 extracts of the pericarps of Mallotus japonicus showed potential anti-tumor-promoter activity. Seven constituents of the CHCl3 extract and two derivatives from the most abundant constituent, mallotojaponin, markedly inhibited the incorporation of 3H-choline into phospholipids of C3H101/2 cells enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter.Keywords
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