The Effect of Vitamin A Acid on the Middle Ear of the Guinea Pig
- 1 April 1981
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 107 (4) , 230-232
- https://doi.org/10.1001/archotol.1981.00790400032007
Abstract
• The bulla in guinea pigs was filled with 0.01%, 0.1%, and 0.5% vitamin A acid (retinoic acid) solution once or twice daily for an average of five days. Pure arachnoid oil was used as a control solution. The mucous membrane appeared normal in the ears receiving arachnoid oil or 0.01% vitamin A acid. In bullae receiving 0.1% and 0.5% solutions, the epithelium remained close to normal, but there were small areas of ossification that were particularly notable in the submucosal layer. There was no indication that the normal guinea pig mucosa showed a metaplastic change into a secreting gland, forming epithelium. (Arch Otolaryngol 1981;107:230-232)This publication has 7 references indexed in Scilit:
- Problems and Pitfalls in Ototoxicity TestingActa Oto-Laryngologica, 1980
- The Ototoxic Potential of Propylene Glycol in Guinea PigsJAMA Otolaryngology–Head & Neck Surgery, 1978
- Organ Culture Studies On Human Skin And Cholesteatoma Epithelium: Contact With Connective Tissue And Exposure To Vitamin AActa Oto-Laryngologica, 1978
- Effect of vitamin A on epithelial morphogenesis in vitro: Fine structural changes in explants of adult mammalian skinExperimental Cell Research, 1973
- Effects of excess vitamin A on cultures of skin from the tail and pads of the embryonic rat, and from the trunk, tail and pads of the embryonic rabbitExperimental Cell Research, 1965
- Das Verhalten der Paukenschleimhaut gegenüber einigen in der Otochirurgie anwendbaren MedikamentenPublished by Springer Nature ,1964
- Metaplasia produced in cultures of chick ectoderm by high vitamin AThe Journal of Physiology, 1953