Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications

This publication has 7 references indexed in Scilit:

• BCH-2763, a Novel Potent Parenteral Thrombin Inhibitor, Is an Effective Antithrombotic Agent in Rodent Models of Arterial and Venous Thrombosis – Comparisons with Heparin, r-Hirudin, Hirulog, Inogatran and Argatroban
  Thrombosis and Haemostasis, 1998
• New routes to conformationally restricted peptide building blocks: a convenient preparation of bicyclic piperazinone derivatives
  Bioorganic & Medicinal Chemistry Letters, 1996
• Chapter 6. Thrombin and Factor Xa Inhibition
  Published by Elsevier ,1996
• Stereoselective Addition of Grignard-Derived Organocopper Reagents to N-Acyliminium Ions: Synthesis of Enantiopure 5- and 4,5-Substituted Prolinates
  The Journal of Organic Chemistry, 1995
• Hirudin and Hirulog: Advances in antithrombotic therapy
  Perspectives in Drug Discovery and Design, 1994
• Thrombin structure and function
  Blood Coagulation & Fibrinolysis, 1991
• Activation of platelets by alpha-thrombin is a receptor-mediated event. D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone-thrombin, but not N alpha-tosyl-L-lysine chloromethyl ketone-thrombin, binds to the high affinity thrombin receptor.
  Journal of Biological Chemistry, 1986