BISMUTH SUBNITRATE IN THE TREATMENT OF ARTERIAL HYPERTENSION

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Abstract
Curative therapy must be based on etiology. The etiology of arterial hypertension is complex; anything that irritates the arteriolar musculature or stimulates the sympathetic pressor fibers may represent the original cause of hypertensive vascular disease. These irritants are many;1endocrine disturbances, dietary irritants, infections, intoxications with metals or chemical irritants, anemia and predisposition to early fatigue of the vascular structures represent some of the known factors. These factors may be spoken of as "initiating factors." In addition, the arteriolar disease of hypertension tends to perpetuate itself even if the irritative factors are no longer operative.2The pathogenesis of hypertension may be best visualized from the diagram. The perpetuating factor is the vicious circle of vascular spasticity causing muscular fatigue, the fatigue leading to increasing arteriolar irritability, and in turn more spasticity and fatigue. Fatigue is amenable to rest; exhaustion, muscular degeneration and fibrosis are irreparable.1Clinical experience

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