Phytochemical constituens ofCirsium setidens Nakai and their cytotoxicity against human cancer cell lines
- 1 October 2002
- journal article
- Published by Springer Nature in Archives of Pharmacal Research
- Vol. 25 (5) , 628-635
- https://doi.org/10.1007/bf02976934
Abstract
Five terpenes (1~5), three fatty acids (6~8), two sterols (9 and 11), and a monogalactosyldiacyl glycerol (10) were isolated from the methylene chloride extract of the aerial part ofCirsium setidens. Their chemical structures were determined to be α-tocopherol (1), 25-hydroper-oxycycloart-23-en-3p-ol (2), 24-hydroperoxycycloart-25-en-3(3-ol (3), mokko lactone (4), transphytol (5), 9, 12, 15-octadecatrienoic acid (6), 9, 12-octadecadienoic acid (7), hexadecanoic acid (8), acylglycosyl β-sitosterol (9), (2R)-1, 2-0-(9z, 12z, 15z-dioctadecatrienoyl)-3-0-β-D-galactopyranosyl glycerol (10) and p-sitosterol glucoside (11) by spectral evidences. Compound3 exhibited significant cytotoxic activity against five human cancer cell lines with its ED50 values ranging from 2.66 to 11.25 μ.M.Keywords
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