Phenothiazine Derivatives. I. Synthesis of Sulfoxide and Sulfone Homologs of Chlorpromazine.

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Abstract
The synthesis of theoretically possible four derivatives of chlorpromazine was described, in which the ring sulfur and then the nitrogen of lateral side chain were oxidized. The sulfone derivatives could not be derived from chlorpromazine itself, but could be prepared by the condensation of N, N-dimethyl-3-chloropropylamine with 2-chlorophenothiazine 5-dioxide, which was easily synthesized via 2-chloro-10-acetylphenothiazine.

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