Role of adenosine deaminase in activation of macrophages
- 1 April 1981
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 32 (1) , 394-397
- https://doi.org/10.1128/iai.32.1.394-397.1981
Abstract
The intracellular adenosine deaminase activity of induced macrophages was twice that of resident cells. Coformycin, a specific inhibitor of adenosine deaminase, inhibited the activation of macrophages, as measured by superoxide generation.This publication has 12 references indexed in Scilit:
- STRUCTURAL STUDIES OF FC RECEPTORS .1. BINDING PROPERTIES, SOLUBILIZATION, AND PARTIAL CHARACTERIZATION OF FC RECEPTORS OF MACROPHAGES1979
- SENSITIVE AND RAPID METHOD FOR DETERMINATION OF SUPEROXIDE-GENERATING ACTIVITY OF BLOOD MONOCYTES AND ITS USE AS A PROBE FOR MONOCYTE FUNCTION IN CANCER-PATIENTS1979
- Increased superoxide anion production by immunologically activated and chemically elicited macrophagesThe Journal of Experimental Medicine, 1978
- Adenosine deaminase inhibition for immunosuppression.1977
- A role for adenosine deaminase in human monocyte maturation.Journal of Clinical Investigation, 1976
- Inhibition of maturation of human precursor lymphocytes by coformycin, and inhibitor of the enzyme adenosine deaminaseThe Journal of Experimental Medicine, 1976
- Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis.Journal of Clinical Investigation, 1976
- ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITYThe Lancet, 1972
- Mode of inhibition of coformycin on adenosine deaminase.1967
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951