Studies on Human Sexual Development. VI. Concentrations of Unconjugated Dehydroepiandrosterone, Estradiol, and Estriol in Amniotic Fluid throughout Gestation*

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Abstract
Concentrations of unconjugated dehydroepiandrosterone, estradiol, and estriol were measured in samples of amniotic fluid from uneventful pregnancies of 9–40 weeks conceptual age. There was no apparent influence of fetal sex upon the levels of these steroids. Dehydroepiandrosterone concentrations rose slightly from 9–20 weeks, and then showed little further change. Estradiol concentrations declined slightly from 9–20 weeks; after 32 weeks gestation, there was a 2-fold rise to term. Estriol levels rose in almost exponential fashion throughout gestation.

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