Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes
- 1 March 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in International Immunology
- Vol. 1 (1) , 43-49
- https://doi.org/10.1093/intimm/1.1.43
Abstract
Interleukin-2 (IL-2) plays an essential role In the clonal expansion of antigen-activated T lymphocytes (T cells). In fact, the expression of both IL-2 and IL-2 receptor (IL-2R, p55, CD25) genes is transiently induced upon T cell activation through the Interaction of antigen/lmajor histocompatibility complex (MHC) and T cell receptor complex. To elucidate the mechanism(s) of the induced gene expression for IL-2 and IL-2R, we have investigated for the presence of potential transcription factors that specifically interact wlth regulatory cis -elements. Here, we demonstrate that one such factor mediates the induced expression of both genes. Interestingly, the recognition sequences by thls factor are significantly dlverse in these two genes and are related to those of Immunoglobulin (Ig) k chain and MHC class I genes. We provlde evidence that this factor indeed binds to the IL-2, IL-2R, and Ig sequence elements with different affinities, thereby affecting the magnitude of gene expression. Interestingly, this factor also binds to other cytokine genes, such as interleukin-6 (IL-6), Interferon-γ (IFN-γ), and HIV-1 and HTLV-1 LTR sequences.Keywords
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