Structural Analogues of the Bimetallic Reaction Center in Acetyl CoA Synthase: A Ni−Ni Model with Bound CO
- 25 June 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (29) , 8700-8701
- https://doi.org/10.1021/ja035606c
Abstract
Models for the active site of the acetyl CoA synthase (ACS) were synthesized by attachment of Cu+ and Ni(0) to nickel diaminodithiolate (S 2 N 2) and diamidodithiolate (S 2 N 2‘) complexes. The Ni−Ni species form stable CO adducts, i.e., [{(CO)2Ni}{NiS 2 N 2‘}]2-, whereas the Cu-NiS 2 N 2 and Cu-NiS 2 N 2‘ models do not. These results provide supporting evidence for a biological role for reduced nickel in ACS.Keywords
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