The Saccharomyces cerevisiae Phosphatase Activator RRD1 Is Required to Modulate Gene Expression in Response to Rapamycin Exposure
Open Access
- 1 February 2006
- journal article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 172 (2) , 1369-1372
- https://doi.org/10.1534/genetics.105.046110
Abstract
We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth.Keywords
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