Somatostatin, Substance P and [Lys]-Vasopressin Interfere with the Binding of [3H][D-Ala2, Met5]Enkephalinamide to Rat Brain Membranes

Open Access
Publisher Website
Google Scholar
Abstract
Somatostatin and substance P (10(-6)-3 X 10(-5) M) inhibited dose-dependently the specific binding of [3H] [D-Ala2, Met5]enkephalinamide [( 3H]-DALAMID) to rat brain membranes, by decreasing the number of binding sites. [Lys]-Vasopressin also inhibited the binding, by affecting both the number of binding sites and the affinity of receptors to [3H]DALAMID. The results indicate that somatostatin and substance P may interfere with the endorphin system by an apparently competitive manner.