AN IMPROVED SYNTHESIS OF tert‐ BUTYLOXYCARBONYL‐L‐HISTIDINE

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Abstract
In our investigations on the effect of replacement of histidine by homohistidine (I) on the biological activity of some peptide‐hormones, relatively large quantities of Boc‐ homohistidine were required. Homohistidine being difficult to synthesize, it was essential to find an effective way of introducing the Boc‐group. In the past, many syntheses of Boc‐histidine were reported (2–6), none of which proved to be quite satisfactory. However, by modifying the procedure of Flouret et al. (6) a convenient method resulting in a high yield of Boc‐histidine and Boc‐homohistidine was found.