Relation of Gonad Hormones to X-Irradiation Sensitivity in Mice.

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Abstract
Male CF, mice were surgically castrated and allowed to make full recovery (1 week) and some were injected with 0.166 mg estradiol benzoate in sesame oil. Ten days later all males were given 625 r whole body penetrating X irradiation, which is minimal LD 100/30 days for the males of this strain. The differential in survival of male and female mice, when exposed to whole body X irradiation, seems to be due in part to the gonadal hormone present. Intact males, with the normal quota of testosterone, show greater mortality than do castrate males. Further, castrate males injected with estradiol benzoate exhibit maximum survival, approaching that of the intact female.