A new role for CCR5 in innate immunity – binding to bacterial heat shock protein 70
Open Access
- 1 September 2006
- journal article
- editorial
- Published by Wiley in European Journal of Immunology
- Vol. 36 (9) , 2293-2295
- https://doi.org/10.1002/eji.200636551
Abstract
CCR5 has been associated with adaptive immune responses, because of its expression on effector and memory T cells, and dentric cells. In this issue of the European Journal of Immunology, Whittall et al. identify CCR5 as a receptor that binds bacterial heat shock protein 70 (HSP70). Thus HSP70 may stimulate responses by CCR5+ T cells or dendritic cells, particularly at epithelial surfaces. These findings imply a role for CCR5 in innate immunity, in addition to its more established role as a chemoattractant receptor for adaptive immune responses.See accompanying article http:dx.doi.org/10.1002/eji.200635953Keywords
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