Specificity of Rat Xenogeneic Cell-Mediated Cytolysis for the Products of the K and D Loci of the Mouse H-2 Complex
Open Access
- 1 May 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 118 (5) , 1795-1798
- https://doi.org/10.4049/jimmunol.118.5.1795
Abstract
Lewis rat lymph node (LN) cells, when cultured with irradiated mouse spleen cells, develop cytotoxic effectors that were shown to be specific for the sensitizing mouse strain. Alloantisera directed to the products of the K and D loci of the target inhibited cytolysis whereas an antiserum to the I region gene products did not inhibit cytolysis even though LPS-induced spleen blasts were used as targets. Thus, it appears that even when effector cells from another species are generated to mouse spleen cells, the gene products of the K and D loci continue to play a predominant role.This publication has 3 references indexed in Scilit:
- Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells.The Journal of Experimental Medicine, 1976
- Specific Selection of Cytotoxic Effector Cells: The Generation of Cytotoxic T Cells in Rat Thoracic Duct Lymphocyte Populations Positively or Negatively Selected for Reactivity to Specific Strong Histocompatibility AlloantigensThe Journal of Immunology, 1976
- GRAFT VERSUS HOST REACTION IN TISSUE CULTURE .I. LYSIS OF MONOLAYERS OF EMBRYO MOUSE CELLS FROM STRAINS DIFFERING IN H-2 HISTOCOMPATIBILITY LOCUS BY RAT LYMPHOCYTES SENSITIZED IN VITRO1968