Macroglobulinemia with Unusual Vascular Changes

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Abstract
The retinopathy of macroglobulinemia has been described by several authors.1-6 The characteristic findings consist of venous dilatation and tortuosity, hemorrhages, and occasional central or branch vein occlusions. Specific mention of associated arterial changes has not been made previously. The following case report is of a patient with macroglobulinemia with the characteristic retinopathy plus unusual arterial changes and microaneurysms. Report of Case A 61-year-old white man was first hospitalized at the University Hospitals on Jan. 6, 1960, because of repeated epistaxis and weakness. The history revealed that he had had periodic epistaxis for the past five years and had noted the onset of fatigue and weakness, progressive in nature, two years ago. At that time he had consulted his local physician and was found to be anemic. The anemia was unresponsive to many types of therapy and was severe enough to require repeated transfusions, the first being given one and

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