EXPERIMENTAL HYPERTENSION FOLLOWING CAROTICOAORTIC DENERVATION IN THE RABBIT

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Abstract
1. The results of denervation of the carotid sinuses and section of the aortic (“depressor”) nerves on the blood‐pressure in the rabbit are recorded.2. An increase in the blood‐pressure resulted from bilateral removal of these “buffer” mechanisms, but in a considerable proportion of the experimental animals the increase was not permanent. The possible explanations of this phenomenon are discussed.3. Pathological changes in the heart and aorta followed the operative interferences and are described.4. The adequacy of the methods used for denervation was demonstrated by the use of neuro‐histological techniques. No evidence for the regeneration of nerve‐endings in the vessel walls was found.5. It is indicated that bilateral vagotomy is necessary for the complete removal of the afferent pathways subserving the caroticoaortic depressor reflexes.

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