The Relationship of Lymphocytes in Blood and in Lymph to Sleep/Wake States in Sheep
Open Access
- 1 March 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Sleep
- Vol. 23 (2) , 1-6
- https://doi.org/10.1093/sleep/23.2.1e
Abstract
Based on evidence of a role for immune-associated cytokines in sleep induction, we investigated the possibility that lymphocyte distribution between blood and lymphatics could be altered as a function of sleep/wakefulness. Blood and lymph sample were obtained from 5 sheep during periods of slow-wave sleep and wake. Blood and lymph lymphocytes were phenotyped using monoclonal antibodies against CD4, CD8, gd T-cell receptors and a surface marker on ovine B cells. Lymph flow rates and efferent lymph cell output were measured. Lymph flow and prescapular efferent lymphocyte output were reduced during sleep compared to wakefulness (p<0.0005). There were no differences in lymphocyte subsets in the blood and in the lymph during sleep/wake brain states. These data indicate that migration of cells in the peripheral lymphatic system is altered during sleep compared to wakefulness.Keywords
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