Increased stem cell dose, as obtained using currently available technology, may not be sufficient for engraftment of haploidentical stem cell transplants

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Abstract
The best strategies for haploidentical stem cell transplants are not known. we used a standard myeloablative pretransplant conditioning regimen (30 mg/kg vp-16, 120 mg/kg cyclophosphamide, and 12 gy of tbi in six fractions), an increased peripheral stem cell dose of >10 × 106 CD34+ cells/kg, T cell depletion (with CD34+cell selection and CD4/CD8 depletion steps) to 24 and >3 (2) months after transplant. Seven patients died: four of transplant related complications and three of relapse. Increased stem cell dose (10 × 106 CD34+ cells/kg) as obtained using currently available technology may not be sufficient to ensure stable engraftment in patients with high-risk leukemia using standard myeloablative conditioning regimens. Bone Marrow Transplantation (2000) 26, 1033–1036.

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