Cocaine and Catecholamine Interaction: A Review

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Abstract
The first part of this review describes the pharmacology of cocaine, followed by a short summary of the metabolism, storage, and release of norepinephrine. The remainder discusses possible interactions between cocaine and drugs whose main effector site is the adrenergic neurone. The following medications are mentioned: methyldopa, imipramine, chlorpromazine, monamine oxidase inhibitors, guanethidine, reserpine, phentolamine hydrochloride, propranolol, and epinephrine. The mechanism of drug reactions which may give rise to hypertensive crises and may be responsible for serious complications or death in patients undergoing minor surgery under local anesthesia are described. Knowledge of these interactions will be helpful in preventing serious mishaps.

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