Change of intracellular calcium of neural cells induced by extracellular ATP
- 24 June 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 284 (2) , 235-237
- https://doi.org/10.1016/0014-5793(91)80693-w
Abstract
Exposure of various neural cells to ATP increased intracellular Ca2+ and the production of inositol trisphosphate. The Ca2+ responses were also observed in the absence of extracellular Ca2+, suggesting that a part of Ca2+ mobilization took place from cytosolic storage. Since adenosine had no effect on intracellular Ca2+ increment, ATP appears to act through a P2‐purinergic receptor. Islet‐activating protein or pertussis toxin pretreatment hardly influenced the increase in intracellular Ca2+ and inositol trisphosphate production induced by ATP, suggesting that IAP‐sensitive GTP‐binding proteins do not play a practical role in this reaction.Keywords
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