Studies on the Mechanism of Mucin Secretion by Cells of the Porcine Tracheal Epithelium

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Abstract
Effects of pharmacological agents on mucin secretion by the tracheal epithelium of piglets were studied using organ culture. Mucin release into the culture medium was reduced, and mucin retention by secretory cells of the mucosa and submucosal glands was increased, by colchicine, vinblastine sulfate and cytochalasin B. Dibutyryl cAMP had no significant effect. Although these agents have diverse and poorly understood influences on cell functions, results suggest a possible role for microtubules and microfilaments in the intracellular movement and release of mucin.