PREVALENCE OF CYTOMEGALOVIRUS ANTIBODIES IN NORWEGIAN KIDNEY‐TRANSPLANT RECIPIENTS AND THEIR LIVING DONORS

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Abstract
Sera (376) from Norwegian kidney transplant recipients and their living, related donors, were tested for the presence of cytomegalovirus antibodies (CMV-ab) by the complement fixation test (CF) and for IgG CMV-ab by the enzyme-linked immunosorbent assay (ELISA). Whenever the results of the 2 methods differed, the sera were also tested by the indirect fluorescent antibody test (FAT). Of 376 sera, 325 showed corresponding results, giving a concordance of 86% between CF and ELISA, ELISA being the more sensitive of the 2, with a sensitivity in the same range as FAT, and high specificity with only 0.3% false-positive results. The prevalence of CMV-ab in Norwegian kidney transplant recipients and their living, related donors, differed very little. The overall CMV-ab seropositivity was 76%. The prevalence increased from 50% at the age of 20 yr to 80% at 30 yr and 90-100% from 60 yr.