The metabolism of trimipramine in the rat
- 20 December 1990
- journal article
- research article
- Published by Wiley in Journal of Mass Spectrometry
- Vol. 19 (13) , 793-806
- https://doi.org/10.1002/bms.1200191303
Abstract
Studies on the metabolism of the tricyclic antidepressant trimipramine, 5-(3-dimethylamino-2-methylpropyl)-10, 11-dihydro-5H-dibenz[b, f] azepine, in the rat are described. Many metabolites of trimipramine (TMP) were isolated from rat urine after enzymatic hydrolysis and their structures were identified by a gas chromatographic/mass spectrometric method, before and after appropriate chemical derivatization. Besides unchanged TMP, 20 metabolites were characterized (underivatized, and after acetylation), of which 12 had undergone alicyclic (C10 or C11) oxidation. This is a hitherto unreported metabolic pathway for TMP in the rat.This publication has 20 references indexed in Scilit:
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