A NEW METHOD FOR ENANTIOSELECTIVE SYNTHESIS OF β-HYDROXY-α-AMINO ACIDS
- 5 February 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 10 (2) , 279-282
- https://doi.org/10.1246/cl.1981.279
Abstract
Highly optically active threo-β-hydroxy-α-amino acids were obtained by the successive treatment of the chiral hydroxy imine 1, prepared by the condensation of t-butyl glycinate with a chiral ketol 3, with methylmagnesium iodide, potassium diisopropylamide and aldehyde.Keywords
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