Alcohol and endometrial cancer risk: Findings from an Italian case‐control study

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Abstract
Using data from a case‐control study conducted in Northern Italy, we analyzed the relation between alcohol drinking and risk of endometrial cancer. Cases were 726 patients, 0 ≤ 1, >1 ≤ 2 and >2 drinks/day (χ%2 1 trend 11.33, p < 0.001). The estimates were similar when wine only (which represents the large majority of all alcohol intake in Italy) was considered, whereas data were less informative for beer and spirits intake only. No relation emerged between duration of alcohol consumption and risk of endometrial cancer. These findings suggest a potential link between alcohol drinking and endometrial cancer risk and are, in any case, inconsistent with a protective role of alcohol in endometrial carcinogenesis. However, several inconsistencies in the epidemiological and biologic evidence leave open the question of causality of this association.

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