THE FILTRATION AND SECRETION OF EXOGENOUS CREATININE IN MAN

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Abstract
A comparison of the rate of excretion of xylose, urea and (exogenous) creatinine in 47 observations on 13 normal adult men yields the following figures for the cc. of plasma cleared per min. per sq. m. of body surface: urea, 36.6; xylose, 52.9; creatinine, 91.4. It is concluded that a quantity of creatinine is removed from the blood by some mechanism other than glomerular filtration, amounting on the average to 74% of the filtered quantity, or 42.5% of the total creatinine excreted. This additional moiety is believed to be excreted by tubular secretion.

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